Mesenchymal stem cells can prevent or promote the progression of colon cancer based on their timing of administration.

Weiqian Hu,Weijun Wang,Xin Jiang,Zeyu Wang,Rong Lin

Journal of translational medicine（2023）

引用 3|浏览6

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摘要

MSCs can curb the progression of colon cancer by inducing Treg accumulation via TGF-β at the early stage of inflammatory transformation but promote the progression of colon cancer by inducing a shift in Th1/Th2 immune balance to Th2 through IL-4 secretion at the late stage. And the immune balance of Th1/Th2 influenced by MSCs could be reversed by IL-12.

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关键词

CD4+T cells,Colitis-associated colon cancer,Immunomodulatory,Mesenchymal stem cells

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