Elevations of Extracellular Vesicles and Inflammatory Biomarkers in Closed Circuit SCUBA Divers.

International journal of molecular sciences(2023)

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摘要
Blood-borne extracellular vesicles and inflammatory mediators were evaluated in divers using a closed circuit rebreathing apparatus and custom-mixed gases to diminish some diving risks. "Deep" divers ( = 8) dove once to mean (±SD) 102.5 ± 1.2 m of sea water (msw) for 167.3 ± 11.5 min. "Shallow" divers ( = 6) dove 3 times on day 1, and then repetitively over 7 days to 16.4 ± 3.7 msw, for 49.9 ± 11.9 min. There were statistically significant elevations of microparticles (MPs) in deep divers (day 1) and shallow divers at day 7 that expressed proteins specific to microglia, neutrophils, platelets, and endothelial cells, as well as thrombospondin (TSP)-1 and filamentous (F-) actin. Intra-MP IL-1β increased by 7.5-fold ( < 0.001) after day 1 and 41-fold ( = 0.003) at day 7. Intra-MP nitric oxide synthase-2 (NOS2) increased 17-fold ( < 0.001) after day 1 and 19-fold ( = 0.002) at day 7. Plasma gelsolin (pGSN) levels decreased by 73% ( < 0.001) in deep divers (day 1) and 37% in shallow divers by day 7. Plasma samples containing exosomes and other lipophilic particles increased from 186% to 490% among the divers but contained no IL-1β or NOS2. We conclude that diving triggers inflammatory events, even when controlling for hyperoxia, and many are not proportional to the depth of diving.
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关键词
decompression sickness,diving,exosomes,extracellular vesicles,filamentous actin,hyperoxia,interleukin-1β,microglia,microparticles,nitric oxide synthase,plasma gelsolin
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