Supplementary Figures S1-S7 from PLK1 Phosphorylates PAX3-FOXO1, the Inhibition of Which Triggers Regression of Alveolar Rhabdomyosarcoma

Supplementary Figures S1-S7. Establishment of screening approach (S1); BI 2536 causes apoptosis and cell cycle arrest (S2); PLK1 phosphorylates PAX3-FOXO1 in vitro (S3); PLK4 is overexpressed in tumor biopsies (S4); PLK1 expression does not correlate with MIB1 expression in tumor biopsies (S5); PLK4 silencing reduces PAX3-FOXO1 activity (S6); PLK1 inhibition causes NMYC degradation (S7).