In vivo generation of thrombin in patients with liver disease without apparent evidence of activation of the intrinsic or extrinsic pathway of coagulation.
Journal of thrombosis and haemostasis : JTH(2023)
摘要
This study provides evidence of enhanced thrombin generation in liver disease without detectable activation of the intrinsic or extrinsic pathway. We propose that defective anticoagulant mechanisms highly amplify the low-grade activation of coagulation by either pathway.
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关键词
acute,blood coagulation,cirrhosis,hemostasis,liver failure,thrombosis
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