Synthesis and Biological Evaluation of Gentiopicroside Derivatives as Novel Cyclooxygenase-2 Inhibitors with Anti-Inflammatory Activity.

Guojin Ren,Qili Zhang,Pengfei Xia,Jie Wang, Pengxia Fang,Xiaojie Jin,Xuejing Peng,Yanli Xu,Jian Zhang,Lei Zhao

Drug design, development and therapy（2023）

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摘要

These gentiopicroside derivatives especially and may represent a novel class of cyclooxygenase-2 inhibitors and could thus be developed as new anti-inflammatory agents.

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关键词

anti-inflammatory,cyclooxygenase-2 inhibitors,gentiopicroside derivatives,molecular docking,structural modification

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