Supplementary fig 3 from Select Antitumor Cytotoxic CD8<sup>+</sup> T Clonotypes Expand in Patients with Chronic Lymphocytic Leukemia Treated with Ibrutinib

(A) Frequency of predominant clonotypes as detected by NGS and of the corresponding CD8+ TRBV families as measured by flow cytometry. Grey bars indicate TRBV families that did not have commercially available fluorescent-labelled antibodies. (B) Pie chart of the most expanded clonotypes and expression of granzyme B (GrB). CD8+ GrB+ clonotypes comprising >2% of the repertoire at the time of response are shown in color.-