Supplementary Figure 4 from Overexpression of Sirt7 Exhibits Oncogenic Property and Serves as a Prognostic Factor in Colorectal Cancer

PDF file - 1464KB, Sirt7 mediates ERK1/2 activation and subsequent mitogenic effects.(A) real-time PCR analysis of Sirt7 in THC8307 cells after ectopic expression of different siRNA. (B) Sirt7 induced increase in growth was subsequently rescued with Sirt7 shRNA, mean� SEM, n=3, p<0.001.). (C) Expression of the Sirt7 mutants fails to induce ERK1/2 in 293T cell.