Intestinal ACE2 regulates glucose metabolism in diet-induced obese mice through a novel gut-islet axis mediated by tryptophan.

Qi Chen,Fei Gao,Yuanyuan Gao,Songtao Yang, Jie Cao,Hongjun Deng,Fengying Yang,Ying Wang,Li Yuan

Obesity (Silver Spring, Md.)（2023）

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摘要

This study highlights an essential role of ACE2 in the maintenance of systemic metabolism to optimize the function of the islets through a novel gut-islet axis mediated by Trp. These results provide proof-of-concept evidence for treating obesity and diabetes.

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