Supplementary Figures S1-S5 from CDC42 Inhibition Suppresses Progression of Incipient Intestinal Tumors

Epithelial deletion of Cdc42 abrogates APCMin/+ tumorigenesis (S1); Improved body weight in Catnb(ex3)/+;Cdc42fl/+;Vil-Cre mice (S2); Epithelial Cdc42 deletion alleviated formation of crypt-like foci (S3); Cdc42 deletion reduced Paneth-like cells in microadenoma foci (S4); CASIN treatment arrested LIM1863 tumor organoids (S5).