Supplemental Figures 1-5 from SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents

Supplemental Figure 1. Relative activity of overexpressed SIRT2 in breast cancer cells Supplemental Figure 2. Expression of other sirtuin proteins and HDAC6 in SIRT2 O/E and knockdown cells Supplemental Figure 3. SIRT2 overexpression increases Prdx1 chaperone activity in HEK293 cells treated with H2O2. Supplemental Figure 4. Effects of SIRT2 overexpression on FOXO3A localization Supplemental Figure 5. Schematic of the zebrafish SIRT2 gene and splice-blocking exon 6 morpholino.