Supplemental Figure 5: UAB30 decreased tumor growth in SK-NEP-1 xenografts. from Preclinical Evaluation of UAB30 in Pediatric Renal and Hepatic Malignancies

In the SK-NEP-1 in vivo experiments, the animals fed UAB30 chow, although healthy throughout the experiment, gained weight at a slower rate than animals fed vehicle-treated chow. To demonstrate that the smaller size did not affect the tumor volumes, we calculated a tumor weight to animal weight ratio to correct for the smaller size of the UAB30 treated animals. There was a significant decrease between the tumor : animal weight ratio between animals treated with UAB30 compared to vehicle, demonstrating that decreased animal weight was not responsible for decreased tumor growth.