Saccharin‐catalyzed Multicomponent Cascade Reactions for the Synthesis of 1,2,3,4,6‐pentasubstituted Piperidines
Journal of heterocyclic chemistry(2023)
摘要
A convenient and efficient method is developed for the synthesis of 1,2,3,4,6-pentasubstituted piperidines via a three-component, one-pot domino reaction of beta-ketoesters, aromatic aldehydes, and aromatic amines in the presence of a catalytic amount of saccharin in methanol at 40 degrees C. The desired piperidines could be easily collected through simple filtration with excellent diastereoselectivities.
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