Repurposing FBP1: dephosphorylating I kappa B alpha to suppress NF kappa B

Metabolic enzymes can function as protein kinases and protein phosphatases to govern the phosphorylation status of protein substrates, thereby regulating pivotal cellular activities. A new study published in Cell Research demonstrated that fructose 1,6-bisphosphatase 1 directly dephosphorylates I kappa B alpha to suppress NF kappa B activation and modulate the tumor immune microenvironment.