Opioids-induced inhibition of HERG ion channels and sudden cardiac death, a systematic review of current literature

Adham El Sherbini,Kiera Liblik,Junsu Lee,Adrian Baranchuk,Shetuan Zhang,Mohammad El-Diasty

Trends in cardiovascular medicine（2023）

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摘要

Our findings suggest that certain opioid consumption may result in the inhibition of HERG channels, subsequently prolonging the QTc interval and increasing patient susceptibility to sudden cardiac death.

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关键词

Opioids,HERG channels,Sudden cardiac death,Torsade's de Pointes

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