Engineering second-generation TCR-T cells by site-specific integration of TRAF-binding motifs into the CD247 locus.
Journal for immunotherapy of cancer（2023）
摘要
Our findings offer a promising strategy for improving the intracellular signaling of TCR-T cells and their application in treating solid tumors.
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关键词
T-lymphocytes,cell engineering,costimulatory and inhibitory T-cell receptors,immunotherapy
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