PHOTOBIOMODULATION THERAPY FOR LARGE SOFT DRUSEN AND DRUSENOID PIGMENT EPITHELIAL DETACHMENT IN AGE-RELATED MACULAR DEGENERATION A Single-Center Prospective Pilot Study

Retina (Philadelphia, Pa.)(2023)

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摘要
Purpose:To evaluate visual acuity and morphologic changes after photobiomodulation (PBM) for patients affected with large soft drusen and/or drusenoid pigment epithelial detachment associated with dry age-related macular degeneration.Method:Twenty eyes with large soft drusen and/or drusenoid pigment epithelial detachment age-related macular degeneration were included and treated using the LumiThera Valeda Light Delivery System. All patients underwent two treatments per week for 5 weeks. Outcome measures included best-corrected visual acuity, microperimetry-scotopic testing, drusen volume, central drusen thickness, and quality of life score at baseline and month 6 (M6) follow-up. Data of best-corrected visual acuity, drusen volume, and central drusen thickness were also recorded at week 5 (W5).Results:Best-corrected visual acuity significantly improved at M6 with a mean score gain of 5.5 letters (P = 0.007). Retinal sensitivity decreased by 0.1 dB (P = 0.17). The mean fixation stability increased by 0.45% (P = 0.72). Drusen volume decreased by 0.11 mm(3) (P = 0.03). Central drusen thickness was reduced by a mean of 17.05 & mu;m (P = 0.01). Geographic atrophy area increased by 0.06 mm(2) (P = 0.01) over a 6-month follow-up, and quality of life score increased by 3,07 points on average (P = 0.05). One patient presented a drusenoid pigment epithelial detachment rupture at M6 after PBM treatment.Conclusion:The visual and anatomical improvements in our patients support previous reports on PBM. PBM may provide a valid therapeutic option for large soft drusen and drusenoid pigment epithelial detachment age-related macular degeneration and may potentially slow the natural course of the disease.
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关键词
pigment epithelial detachment,large soft drusen,degeneration,age-related
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