Diagnostic accuracy of morning serum cortisol concentration in predicting secondary adrenal insufficiency

Adrenal insufficiency (AI) can be a life-threatening disease, which is why patients at risk of having secondary AI due to pituitary disease and/or its management typically undergo periodic evaluation with dynamic testing. This is typically done with the 250 µg Synacthen stimulation test (SST), which is itself safer, less disagreeable and less resource intensive than the, now superseded, insulin stress test. However, we propose a more rapid, convenient and cost-effective method based on the basal serum cortisol threshold This article is protected by copyright. All rights reserved.