PTPN2 is a Critical Regulator of Ileal Paneth Cell Viability and Function in Mice.

Vinicius Canale,Marianne R Spalinger,Rocio Alvarez,Anica Sayoc-Becerra,Golshid Sanati,Salomon Manz,Pritha Chatterjee,Alina N Santos,Hillmin Lei, Sharon Jahng,Timothy Chu,Ali Shawki,Elaine Hanson,Lars Eckmann,André J Ouellette,Declan F McCole

Cellular and molecular gastroenterology and hepatology（2023）

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摘要

Constitutive Ptpn2-deficiency affects Paneth cell viability and compromises Paneth cell-specific AMP production. The observed effects may contribute to the increased susceptibility to intestinal infection and dysbiosis in these mice.

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关键词

Antimicrobial peptides,TCPTP,inflammatory bowel disease,intestinal epithelial cells,lysozyme,microbiome

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