Prediction of Longitudinal Cognitive Decline in Preclinical Alzheimer Disease Using Plasma Biomarkers.

Niklas Mattsson-Carlgren,Gemma Salvadó,Nicholas J Ashton,Pontus Tideman,Erik Stomrud,Henrik Zetterberg,Rik Ossenkoppele,Tobey J Betthauser,Karly Alex Cody,Erin M Jonaitis,Rebecca Langhough,Sebastian Palmqvist,Kaj Blennow,Shorena Janelidze,Sterling C Johnson,Oskar Hansson

JAMA neurology（2023）

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摘要

In this study, plasma P-tau217 predicted cognitive decline in patients with preclinical AD. These findings suggest that plasma P-tau217 may be used as a complement to CSF or PET for participant selection in clinical trials of novel disease-modifying treatments.

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关键词

longitudinal cognitive decline,preclinical alzheimer disease,prediction

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