Blockade of KLF5/LDH-A feedback loop contributes to Curcumol inhibition of sinusoidal endothelial cell glycolysis and mitigation of liver fibrosis.

Yang Li,Yuanyuan Zhou,Siwei Xia,Li Chen,Ting Yang,Danli Zhao,Zili Zhang,Jiangjuan Shao,Xuefen Xu,Feng Zhang,Shizhong Zheng

Phytomedicine : international journal of phytotherapy and phytopharmacology（2023）

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摘要

Our results demonstrated the great utilization potentiality of KLF5 in liver fibrosis, and the innovative discovery that LDH-A regulates the glycolytic process and forms a malignant feedback loop by exerting non-enzymatic effects. It also reveals the prospect of Curcumol-regulated KLF5/LDH-A feedback loop in the treatment of liver fibrosis, providing a new option for the future medicine of liver fibrosis.

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关键词

Curcumol,Glycolysis,Krüppel-like factor 5,Lactate dehydrogenase-a,Liver fibrosis,Liver sinusoidal endothelial cell

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