Single-nucleotide polymorphisms of matrix metalloproteinase genes are associated with graft fibrosis after kidney transplantation.

Hengcheng Zhang,Xiang Gao,Zeping Gui,Chuanjian Suo,Jun Tao,Zhijian Han,Xiaobin Ju,Ruoyun Tan,Min Gu,Zijie Wang

Translational andrology and urology（2023）

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摘要

The SNP rs9059 is associated with significant kidney allograft pathological changes by promoting EMT progression. Our findings provide insights into the etiology of renal allograft interstitial fibrosis and the MMP9 could be used as a potential treatment target in the future.

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关键词

Matrix metalloproteinase,kidney transplantation,next-generation sequencing,renal fibrosis,single-nucleotide polymorphisms

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