Induction of Innate Inflammatory Pathways in the Corneal Epithelium in the Desiccating Stress Dry Eye Model.

Zhiyuan Yu,Ghasem Yazdanpanah,Jehan Alam,Cintia S de Paiva,Stephen Pflugfelder

Investigative ophthalmology & visual science（2023）

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摘要

These findings indicate innate NF-kB and NLRP3 inflammasome inflammatory pathways are induced in the corneal epithelium within one day in the DS dry eye model. NF-kB activation was associated with increased expression of inflammatory mediators involved in dry eye. Induction of these pathways is accompanied by increased bound/total IL-18 and mature IL-1β.

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关键词

innate inflammatory pathways,corneal epithelium,eye

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