Candimine from Hippeastrum escoipense (Amaryllidaceae): Anti-Trypanosoma cruzi activity and synergistic effect with benznidazole.

Javier E Ortiz,Mauricio Piñeiro,Nieves Martinez-Peinado,Patricia Barrera,Miguel Sosa,Jaume Bastida,Julio Alonso-Padilla,Gabriela E Feresin

Phytomedicine : international journal of phytotherapy and phytopharmacology（2023）

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摘要

The synergism between Cnd and Bzn indicates that the combination at the concentration of 4×IC could be useful as an effective new therapy against CD in the chronic stage. Thus, Cnd isolated from the leaves of H. escoipense emerges as potential candidate for the development of a new drug for the treatment of CD.

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关键词

Amaryllidaceae alkaloids,Antiparasitic assays,Candimine,Chagas disease,Neglected disease,Trypanosoma cruzi

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