Sulfenylation links oxidative stress to protein disulfide isomerase oxidase activity and thrombus formation.

Moua Yang,Joyce Chiu,Christina Scartelli,Nathan Ponzar,Sachin Patel,Anika Patel,Renan B Ferreira,Robert F Keyes,Kate Carroll,Nicola Pozzi,Philip J Hogg,Brian C Smith,Robert Flaumenhaft

Journal of thrombosis and haemostasis : JTH（2023）

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摘要

PDI sulfenylation is a critical post-translational modification that is an intermediate during disulfided PDI formation in the setting of oxidative stress. Oxidants generated by vascular cells during activation promote PDI sulfenylation, and interference with PDI during oxidative stress impairs thrombus formation.

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关键词

Cysteine,Disulfide,Oxidation-Reduction,Protein Disulfide Isomerase,Sulfenylation,Thrombosis

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