Ara h 2-specific IgE epitope-like peptides inhibit the binding of IgE to Ara h 2 and suppress lgE-dependent effector cell activation.

Peter Korošec,Ana Koren,Jerneja Debeljak,Abida Zahirović,Maja Skerbinjek-Kavalar,Vojko Berce,Luka Dejanović,Jernej Luzar,Borut Štrukelj,Mojca Lunder

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology（2023）

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摘要

These studies show that the indicated peptides reduce the allergenic activity of Ara h 2 and suppress lgE-dependent basophil and mast cell activation. These observations may suggest a novel therapeutic strategy for food allergy based on epitope-paratop blocking.

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关键词

Ara h 2,ImmunoCAP inhibition,basophil activation test,epitopes,mast cell activation test,paratopes,peanut allergy,peptides,specific IgE

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