Drug binding and drug-drug interaction considerations in individuals with obesity before and after bariatric surgery: A retrospective cross-sectional study

Emerita Quintina de Andrade Moura, Carolina Dumke de Siqueira, Ana Carolina Martins, Bruno Fonseca Nunes,Ana Carolina Rabello de Moraes,Fabíola Branco Filippin-Monteiro

Medicine in Drug Discovery（2023）

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摘要

•Protein binding is altered after bariatric surgery and impacts the pharmacodynamics of certain drugs.•Serum AAG showed a significant reduction after 12 months of surgery, which can influence the free fraction of drugs with a high-affinity rate, including antidepressants.

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关键词

α-1 acid glycoprotein,Obesity,Bariatric surgery,Protein binding

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