Synthesis and structural characterization of a novel palbociclib-kaempferol cocrystal with improved tabletability and synergistic antitumor activity
Journal of Molecular Structure(2023)
摘要
•A novel palbociclib-kaempferol (PAL-KAE) cocrystal was synthesized by antisolvent cocrystallization.•The obtained PAL-KAE cocrystal was characterized comprehensively by SCXRD, PXDR, DSC, FT-IR, SEM, HS, and MEP.•The tabletability of palbociclib was improved through cocrystallization with kaempferol.•PAL-KAE cocrystal showed significantly improved antitumor activity than PAL and KAE over OVCAR3.
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关键词
Palbociclib,Kaempferol,Characterization,Tabletability,Synergistic anticancer activity
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