Aerobic exercise reduced the amount of CHRONO bound to BMAL1 and ameliorated glucose metabolic dysfunction in skeletal muscle of high-fat diet-fed mice.

Lei Xu,Jie Jia,Shudan Miao,Lijing Gong,Jin Wang,Shiyi He,Ying Zhang

Life sciences（2023）

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摘要

These data suggested that aerobic exercise could counterbalance CHRONO interacted with BMAL1 and prevent glucose metabolism dysfunction of skeletal muscle, and finally maintain whole-body insulin sensitivity in the HFD-fed mice.

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关键词

Aerobic exercise,CHRONO-BMAL1 pathway,Glucose metabolism of skeletal muscle,High-fat diet,Insulin sensitivity

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