Design of non-cytotoxic 6,7-dihydroxycoumarin-5-carboxylates with antibiofilm activity against Staphylococcus aureus and Candida albicans .
Organic & biomolecular chemistry(2023)
摘要
The 6,7-dihydroxycoumarin-5-carboxylates DHCou and 4-Me-DHCou have been synthesized five-step route including a propargyl-Claisen rearrangement as key step. The compounds show antibiofilm activity against and but lack the cytotoxic activity of parent 6,7-dihydroxycoumarines such as esculetin and 4-methylesculetin.
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