Mechanism exploration of 6-Gingerol in the treatment of atherosclerosis based on network pharmacology, molecular docking and experimental validation

Youdong Hu,Tingting Liu, Guangzhen Zheng,Li Zhou, Ke Ma, Xiaolian Xiong,Cheng Zheng,Jin Li,Yong Zhu, Wenhui Bian,Xiangde Zheng,Qingping Xiong,Jiafeng Lin

Phytomedicine（2023）

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摘要

The 6-Gingerol can markedly improve atherosclerosis by modulating key multi-targets TP53, RELA, BAX, CASP3, and BCL2 in lipid and atherosclerosis pathways. These novel findings shed light on the anti-atherosclerosis mechanism of 6-Gingerol from the perspective of multiple targets and pathways.

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关键词

6-Gingerol, Atherosclerosis, Network pharmacology, Molecular docking, Experimental validation

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