Early lymphocyte collection for anti-CD19 CART production improves T-cell fitness in patients with relapsed/refractory diffuse large B-cell lymphoma.

T Dubnikov Sharon, M Assayag,B Avni, S Kfir-Erenfeld,E Lebel,M E Gatt, N Goldschmidt,P Stepensky, N Asherie,S Grisariu

British journal of haematology（2023）

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摘要

While improved T-cell phenotype and function in the lymphopheresis product did not translate into significantly improved clinical outcomes, a trend towards better overall survival (OS) and progression-free survival (PFS) was observed. Early lymphopheresis maximizes the potential of salvage therapies, without compromising CAR T-cell quality.

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关键词

CD19-CART,Lymphopheresis,T-cell fitness,relapsed/refractory diffuse large B-cell lymphoma

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