Double trouble: Synchronous and metachronous primaries confound ctHPVDNA monitoring

Saskia Naegele,Vasileios Efthymiou,Shun Hirayama, Brian Y. Zhao,Dipon Das,Annie W. Chan,Jeremy D. Richmon,A. John Iafrate,Daniel L. Faden

Head & Neck（2023）

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摘要

As ctHPVDNA use becomes more prevalent, it is important to recognize that an increase in ctHPVDNA can come not only from the primary tumor or metastatic clones, but also from synchronous or metachronous second primaries.

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关键词

cell-free DNA,circulating tumor DNA,human papillomavirus (HPV),oropharyngeal,sinonasal,squamous cell carcinoma

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