Human lymphocytes mobilized with exercise have an anti-tumor transcriptomic profile and exert enhanced graft-versus-leukemia effects in xenogeneic mice.

Helena Batatinha,Douglass M Diak,Grace M Niemiro,Forrest L Baker,Kyle A Smith,Tiffany M Zúñiga,Preteesh L Mylabathula,Michael D Seckeler,Branden Lau,Emily C LaVoy,Michael P Gustafson,Emmanuel Katsanis,Richard J Simpson

Frontiers in immunology（2023）

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摘要

Exercise in humans mobilizes effector lymphocytes with an anti-tumor transcriptomic profile and their use as DLI extends survival and enhances the graft-versus-leukemia (GvL) effect without exacerbating GvHD in human leukemia bearing xenogeneic mice. Exercise may serve as an effective and economical adjuvant to increase the GvL effects of allogeneic cell therapies without intensifying GvHD.

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NSG mice,adoptive cell therapy,cancer,donor lymphocyte infusions,exercise immunology,graft-versus-host disease,immunotherapy,single cell transcriptomics

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