Supplemental fibrinogen restores thrombus formation in cardiopulmonary bypass-induced platelet dysfunction ex vivo.

Michael Schoerghuber,Thomas Bärnthaler,Florian Prüller,Polina Mantaj,Gerhard Cvirn,Wolfgang Toller,Christoph Klivinyi,Elisabeth Mahla,Akos Heinemann

British journal of anaesthesia（2023）

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摘要

Single valve surgery using moderately hypothermic CPB induces partial platelet dysfunction. Thrombus formation was restored in an experimental study design by ex vivo supplementation of fibrinogen.

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关键词

cardiac surgery,cardiopulmonary bypass,coagulopathy,fibrinogen,platelet dysfunction,thrombus

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