Dapagliflozin modulates neuronal injury via instigation of LKB1/p-AMPK/GABA B R2 signaling pathway and suppression of the inflammatory cascade in an essential tremor rat model.

Ahmed S Kamel,Sama M Farrag,Heba M Mansour,Noha N Nassar,Muhammed A Saad

Expert opinion on therapeutic targets（2023）

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摘要

DAPA offers a potential neuroprotective effect in ET by augmenting the neuronal inhibitory machinery via suppressing the inflammatory and excitotoxicity systems thru LKB1/p-AMPK/GABA R2 signaling.

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关键词

Dapagliflozin,Essential tremor,Glutamate,Harmaline,LKB1/p-AMPK/GABAB R2

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