Stereo-complementary epoxidation of 4-vinyl-2,3-dihydrobenzofuran using mutants of SeStyA with enhanced stability and enantioselectivity

•Thermostabilizing mutations of SeStyA were identified via the consensus approach.•Half-life of combinatory mutants at 40 °C increased up to 25-fold of the wild-type.•Both (R)- and (S)-epoxide were achieved from 4-vinyl-2,3-dihydrobenzofuran.•Enantio-purity of (R)-epoxide was increased from 78% ee to 99% ee.•Inversion of enantioselectivity afforded (S)-epoxide with 99% ee.