Biomarkers for checkpoint inhibitor therapy in mucinous epithelial ovarian cancer.

Thomas Bartl,Anita Alberts,Sofia-Christina Papadopoulos,Andrea Wolf,Leonhard Muellauer,Gerda Hofstetter,Christoph Grimm,Dan Cacsire Castillo-Tong

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society（2023）

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摘要

A sub-group of mucinous ovarian cancers appear to demonstrate a pro-immunogenic tumor environment with high PD-L1 expression, decreased ARID1A expression, and characteristic tumor-infiltrating lymphocyte infiltration patterns. Further clinical validation of anti-PD-L1/PD-1 targeting in selected mucinous ovarian cancers appears promising.

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关键词

cystadenocarcinoma, mucinous

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