Quantifying Immune Cell Force Generation Using Traction Force Microscopy.
Methods in molecular biology (Clifton, N.J.)(2023)
摘要
Immune cells rely on the generation of mechanical force to carry out their function. Consequently, there is a pressing need for quantitative methodologies that permit the probing of the spatio-temporal distribution of mechanical forces generated by immune cells. In this chapter, we provide a guide to quantify immune cell force generation using traction force microscopy (TFM), with a specific focus on its application to the study of the T-cell immunological synapse.
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关键词
Biophysics,Cytoskeleton,Immunological synapse,Mechanical forces,Mechanobiology,T cell activation,Traction force microscopy
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