Chemical characterization of polysaccharides from Arctium lappa root and its hepatoprotective effects on mice
JOURNAL OF FUNCTIONAL FOODS(2023)
摘要
To clarify the structure of Arctium lappa polysaccharide (ALP) with hepatoprotective activity, the ALP with a molecular weight of 2193 Da was purified. It was mainly composed of fructose and glucose (mole ratio = 0.635: 0.284), and little amount of arabinose, galactose and mannose (mole ratio = 0.049: 0.010: 0.021). Structural characterization showed that ALP had a backbone consisted of ->(2-beta-D-Fruf-1)n ->. Histopathological analysis showed that ALP had a protective effect on CCl4-induced liver inflammation. ALP obviously inhibited the level of alanine transaminase, aspartate aminotransferase and inflammatory cytokines, and decreased the mRNA ex-pressions of toll-like receptors 4/nuclear factor-kappaB pathway and the corresponding proteins in liver tissue. In addition, ALP also had antioxidant effects. These results suggested that ALP could be used as a treatment for liver injury and has a broad development prospect.
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关键词
Arctium lappa polysaccharide,Liver injury,TLR4,NF-?B
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