A New family of Sulfamidophosphonates Derivatives: Microwave-Accelerated Multicomponent Synthesis, Characterization and X-Ray Crystallographic Study

In this present study, we describe a simple, effective and greener one-pot microwave-assisted synthesis of novel alpha-sulfamidophosphonates 4(a-l), and 5(a, b) that were rationally designed and synthesized following the principle of the superposition of bioactives substructures. This reaction was accomplished by the condensation of various aromatic aldehydes, sulfamide and diethyl phosphite via the Kabachnik-Fields reaction using ethanol as solvent under catalyst-free conditions. The corresponding products were obtained with good yields, in short reactions time and no side product was observed. All the newly synthesized compounds were systematically characterized by IR, H-1 NMR, C-13 NMR and P-31 NMR analysis and the structures of the compounds 4 b and 4 c were further analyzed by single crystal X-ray diffraction.