Enhancing Resolution of Inferring Hi-C Data Integrating U-Net and ResNet Networks

The Hi-C data is the basis of three-dimensional chromosome structure reconstruction. In this paper, a method integrating U-Net and ResNET network is proposed to infer high resolution Hi-C data from existing low-resolution Hi-C data. Firstly, the U-Net is used as the backbone network to make full use of the shallow layer details and deep layer essential features of Hi-C data. Secondly, the residual module is introduced into the coding path and decoding path of the network to increase the depth of the model and prevent network degradation. Finally, the down sampling is used to reduce the calculation amount to decrease the required running time for the network model. The experimental results on real datasets showed that the proposed method had better performance than existing methods, and the inferred high resolution Hi-C data was closer to the real Hi-C data.