Supplementary Figure S6 from Delivery of Therapeutics Targeting the mRNA-Binding Protein HuR Using 3DNA Nanocarriers Suppresses Ovarian Tumor Growth

Supplementary Fig. S6. Biodistribution of Cy3-conjugated 3DNA +/- conjugation to folic acid (FA). Following systemic delivery of FA-targeted Cy3-3DNA to ovarian tumor bearing mice, significant Cy3 fluorescence was observed in ovarian tumors, lesser amount in normal ovaries of tumor-bearing mice, very low amounts in brain, liver, spleen, and lung (white arrows), and no fluorescence was observed in heart. No fluorescence was observed in the ovary of non-tumor bearing mouse.