Supplementary Figure S4 from Delivery of Therapeutics Targeting the Mrna-Binding Protein HuR Using 3DNA Nanocarriers Suppresses Ovarian Tumor Growth

Supplementary Fig. S4. TUNEL and Ki67 staining for detection of proliferating and apoptotic cells, respectively. A. TUNEL and Ki67 stained sections of four OVCAR5-shHuR and four OVCAR5-shCtrl ovarian xenografts. Areas of Ki67- cells are delineated with a white dotted line. B. In vitro staining of parental OVCAR5 cells, OVCAR5-shCtrl cells and OVCAR5-shHuR cells. Ki67+ cells and DAPI-stained cells were counted in three 1.4mm2 fields to determine % Ki67+ cells. * indicates p = 0.003 between parental and shHuR cells. DAPI stains nuclei in panels A and B. White bar = 50 mm.