Supplementary Figures 1 - 5 from FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K–AKT Pathway

PDF file - 232KB, Figure S1: FoxO subcellular localization under NVP-BEZ235, BKM120, or MK-2206 treatment. Figure S2: Quantified ratios of AKT phosphorylation levels to total AKT levels in FoxO WT and KO cells after 50 nM NVP-BEZ235 treatment. Figure S3: The effect of high dosage NVP-BEZ235 on cell proliferation in FoxO WT and KO cells. Figure S4: Rictor knockdown potentiates cell proliferation suppression and cell death induction in response to NVP-BEZ235 treatment in RCC cells. Figure S5: The expression levels of p27 and Bim in FoxO deficient cells under NVPBEZ235 treatment.