Supplementary Figure 1 from Candidate Pathways for Promoting Differentiation or Quiescence of Oligodendrocyte Progenitor-like Cells in Glioma

PDF file - 1.1MB, Histological and immunocytochemical characterization of the RACS-PDGFb-induced tumors in Ntv-a-Olig2-bacTRAP mice resemble human grade IV malignant glioblastoma. A-A1: Low magnification image of the hematoxylin and eosin stained cryostat section of the large, high grade tumor excised from the Ntv-a/ink4a/arf+/- Olig2::EgfpL10a mouse. Higher magnification of the boxed area in A shows similarities with the human GBM, including pseudopalisades (arrows), surrounding areas of necrosis (asterisk), and vascular proliferation (arrowheads). B: Large number of Olig2-positive cells in the PDGF-B-induced glioblastoma on the Ntv-a/ink4a/arf+/- Olig2: EgfpL10a background are labeled with the antibody against proliferation marker Ki67, confirming high proliferative index of tumor cells