Supplementary Figures S1-S8 from Elucidation of the Roles of Tumor Integrin β1 in the Extravasation Stage of the Metastasis Cascade

In vitro microfluidics-based extravasation assays (S1); Knockdown of β1 integrin results in a reduction in extravasation rate (S2); Extravasation in vivo (S3); Analysis of adhesion rate in an endothelial monolayer microfluidic flow assay (S4); Visualization and scoring of transendothelial migration events in the vertical monolayer device (S5); Tumor cell protrusion dynamics in 3D collagen 1/fibrin mix matrices (S6); β1 integrin is required for invasion past the basement membrane (S7); Role of alpha integrins subunits in transendothelial migration in microvascular networks (S8).