Supplementary Figure 5 from Candidate Pathways for Promoting Differentiation or Quiescence of Oligodendrocyte Progenitor-like Cells in Glioma

PDF file - 506K, Differentiation or Quiescence candidates show similar expression patterns in mouse and human glioma. A: Scatterplot of whole tumor (not TRAP) microarray data (x-axis), compared to normal mouse cortex (y-axis), shows strong enrichment of most OPC genes (blue), except the for DorQ candidates, which show only modest enrichment (purple). For comparison, there is no enrichment of mature oligodendrocyte gene (green). Up to 50 genes shown per class. B: Scatterplot of human proneural tumor microarray data from TCGA (x-axis), compared to normal human brain (y-axis), shows strong enrichment of most OPC genes (blue), and only modest enrichment of DorQ candidates (purple). For comparison, there is no enrichment of mature oligodendrocyte gene (green). C: Scatterplot of log2 fold changes for candidates, OPC and mature oligodendrocyte genes, in human (y-axis) and mouse tumor vs. normal comparisons shows good cross species correlation of gene expression patterns (myelinating oligodendrocytes, red, .44, DORQ candidates, purple, .49, OPC, blue, .62. Pearsons correlations). D: Candidate genes are less enriched then other OPC genes in both human (p<.05), and mouse (p < 1E-6, Welch's T-Test). Myelinating oligodendrocyte genes are shown for comparison