MP65-14 EFFICACY OF POLYACRYLAMIDE GEL (BULKAMID ® ) INJECTION IN PATIENTS WITH MITROFANOFF LEAKAGE AFTER CONTINENT DIVERSION SURGERY: A COMPARISON WITH MACROPLASTIQUE®

You have accessJournal of UrologyCME1 Apr 2023MP65-14 EFFICACY OF POLYACRYLAMIDE GEL (BULKAMID®) INJECTION IN PATIENTS WITH MITROFANOFF LEAKAGE AFTER CONTINENT DIVERSION SURGERY: A COMPARISON WITH MACROPLASTIQUE® Ioannis Loufopoulos, Kapriniotis Konstantinos, Mahreen Pakzad, Anthony Noah, Helena Gresty, Tamsin Greenwell, and Jeremy Ockrim Ioannis LoufopoulosIoannis Loufopoulos More articles by this author , Kapriniotis KonstantinosKapriniotis Konstantinos More articles by this author , Mahreen PakzadMahreen Pakzad More articles by this author , Anthony NoahAnthony Noah More articles by this author , Helena GrestyHelena Gresty More articles by this author , Tamsin GreenwellTamsin Greenwell More articles by this author , and Jeremy OckrimJeremy Ockrim More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003323.14AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: We have previously published outcomes of polydimethylsiloxane (Macroplastique®) in patients with leakage from their Mitrofanoff channels. Macroplastique® has now been replaced by Bulkamid® hydrogel. We present the outcomes of Bulkamid® injection in the last 5 years and compare it to the previous usage of silicone. METHODS: We retrospectively analysed data 2016-2021 for patients who had previously undergone Mitrofanoff channel formation who received Bulkamid® injections for incontinence. Effectiveness was assessed by the number of pads used before and after injection. Outcomes were classified as complete success (dry), partial success (>50% reduction incontinence pads) and failure. We also calculated success by channel type, type of reservoir and for number and volume of injections per treatment. RESULTS: Results are shown on Table. 11 female patients had Bulkamid® injection to their Mitrofanoff channels due to urinary leakage. Mean age was 45.9 (range 21-67) and median follow-up 16 weeks (range 1-44). 9 patients received Bulkamid® injections once, whilst 2 patients received injections twice. Initial injection was partially successful in 4/10 patients (40%) and a second injection in 1 patient (cumulative success rate 45%), but only 1 patient was completely dry (9%).Of the 5 failures, 2 had revision of their Mitrofanoff channels with success. The 5 successful injections were given to 4 patients with Monti channels and 1 with appendiceal channel (3 patients ileocystoplasty and 1 with ileal neobladder). None of the injections given to native bladders were successful. The mean volume of the injected Bulkamid® gel was 1.9mls (range 0.5-4mls). Greater volumes did not improve success rates, as 3/4 successful injections had a volume less than 1.9 ml. Comparison to Macroplastique® showed no statistical difference in the success rates between the two injectable bulking agents. CONCLUSIONS: Bulkamid® injection to Mitrofanoff® channel had a partial response (45%) in the management of incontinence through a Mitrofanoff channel, but was curative in only 9%. Success rates for Bulkamid® seem to be comparable to the ones previously reported for Macroplastique®. Bulking may, at least, defer the necessity for major surgical revision. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e896 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Ioannis Loufopoulos More articles by this author Kapriniotis Konstantinos More articles by this author Mahreen Pakzad More articles by this author Anthony Noah More articles by this author Helena Gresty More articles by this author Tamsin Greenwell More articles by this author Jeremy Ockrim More articles by this author Expand All Advertisement PDF downloadLoading ...