Outcomes of Redo Endoscopic Endonasal Skull Base Surgery for Recurrent or Residual Nonfunctioning Pituitary Adenomas: An Analysis of 93 Consecutive Patients at the University of Pittsburgh Medical Center

Background: Pituitary adenomas account for ~10 to 20% of all intracranial tumors, and nonfunctional adenomas (NFA) are the second most common subtype. NFA recurrence is common, particularly following incomplete resection, and has been reported as 12 to 58% within 5 years. The endoscopic endonasal approach (EEA) has become the mainstay of treatment for symptomatic NFAs, but there is a paucity of data describing the unique challenges and documenting the clinical outcomes and recurrence of NFAs following redo EEA after prior transsphenoidal surgery.