Synovial monocytes contribute to chronic inflammation in childhood-onset arthritis via IL-6/STAT signalling and cell-cell interactions.

Tobias Schmidt,Alma Dahlberg,Elisabet Berthold,Petra Król,Sabine Arve-Butler,Emilia Rydén,Seyed Morteza Najibi,Anki Mossberg,Anders A Bengtsson,Fredrik Kahn,Bengt Månsson,Robin Kahn

Frontiers in Immunology（2023）

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摘要

Synovial monocytes in childhood-onset arthritis are functionally affected and contribute to chronic inflammation, e.g., promoting adaptive immune responses. These data support a role of monocytes in the pathogenesis of oJIA and highlight a group of patients more likely to benefit from targeting the IL-6/JAK/STAT axis to restore synovial homeostasis.

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关键词

monocyte,inflammation,juvenile idiopathic arthritis,JIA,synovial fluid (SF),IL-6,rheumatology

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